GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10862219 | 1 | rs59375902 | chr12:81441561 | ACSS3 | chr12:81471809-81649582:+ | 0.22 | 4.67 | 4.01E-6 | Neuroticism |
| THCA | cis | rs11574514 | 1 | rs59376497 | chr16:67681170 | C16orf86 | chr16:67700717-67702659:+ | -0.32 | -3.85 | 0.000137 | Crohn's disease |
| THCA | cis | rs11574514 | 1 | rs59376497 | chr16:67681170 | LRRC36 | chr16:67360747-67419108:+ | 0.4 | 3.57 | 0.000395 | Crohn's disease |
| THCA | cis | rs11574514 | 1 | rs59376497 | chr16:67681170 | ZDHHC1 | chr16:67428323-67450339:- | 0.39 | 4.27 | 2.4E-5 | Crohn's disease |
| THCA | cis | rs10794720 | 1 | rs59377495 | chr10:1157019 | IDI2 | chr10:1064847-1071799:- | 0.35 | 3.75 | 0.000197 | Chronic kidney disease;Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs12131428 | 1 | rs59394709 | chr1:162427943 | HSD17B7 | chr1:162760496-162782607:+ | 0.29 | 3.46 | 0.000594 | Discordance in emotional problems in monozygotic twins |
| THCA | cis | rs594074 | 1 | rs594074 | chr6:6552994 | LY86 | chr6:6588934-6655216:+ | 0.12 | 3.54 | 0.000442 | Diabetic kidney disease |
| THCA | cis | rs16895812 | 1 | rs59421433 | chr6:42495344 | PRPH2 | chr6:42664334-42690358:- | -0.28 | -3.78 | 0.000177 | Obesity-related traits |
| THCA | cis | rs2129782 | 1 | rs59425875 | chr8:89411899 | MMP16 | chr8:89049462-89339717:- | 0.31 | 5.04 | 6.5E-7 | Electrodermal activity |
| THCA | cis | rs4332428 | 1 | rs59428599 | chr10:4970849 | AKR1C2 | chr10:4964715-5060207:- | 0.33 | 4.38 | 1.45E-5 | Height |
| THCA | cis | rs2129782 | 1 | rs59430846 | chr8:89411781 | MMP16 | chr8:89049462-89339717:- | 0.31 | 5.04 | 6.5E-7 | Electrodermal activity |
| THCA | cis | rs9346353 | 1 | rs59459704 | chr6:70424585 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.37 | 0.000799 | Sleep duration |
| THCA | cis | rs6684514 | 1 | rs59468948 | chr1:156288058 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 5.55 | 4.68E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs59468948 | chr1:156288058 | C1orf85 | chr1:156259882-156265449:- | -0.17 | -4.16 | 3.82E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs59468948 | chr1:156288058 | CCT3 | chr1:156278752-156308195:- | -0.33 | -7.21 | 2.16E-12 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |